Patrick A Dion Selected Research

Hereditary Sensory and Motor Neuropathy (Dejerine Sottas Disease)

1/2016	KCC3 axonopathy: neuropathological features in the central and peripheral nervous system.
1/2013	Potassium-chloride cotransporter 3 interacts with Vav2 to synchronize the cell volume decrease response with cell protrusion dynamics.
3/2012	Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum.
8/2011	Transit defect of potassium-chloride Co-transporter 3 is a major pathogenic mechanism in hereditary motor and sensory neuropathy with agenesis of the corpus callosum.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Patrick A Dion Research Topics

Disease

11	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 12/2021 - 06/2011
6	Parkinson Disease (Parkinson's Disease) 01/2019 - 09/2011
5	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2021 - 08/2011
5	Restless Legs Syndrome (Restless Legs) 01/2019 - 07/2011
4	Hereditary Sensory and Motor Neuropathy (Dejerine Sottas Disease) 01/2016 - 08/2011
3	Corpus callosum agenesis neuronopathy 10/2017 - 08/2011
3	Dementia (Dementias) 01/2017 - 09/2012
2	Schizophrenia (Dementia Praecox) 11/2022 - 01/2015
2	Psychotic Disorders (Schizoaffective Disorder) 11/2022 - 10/2021
2	Nervous System Diseases (Neurological Disorders) 01/2021 - 09/2012
2	Oculopharyngeal Muscular Dystrophy 04/2019 - 06/2007
2	Essential Tremor (Essential Tremors) 01/2017 - 12/2016
2	REM Sleep Behavior Disorder 01/2017 - 11/2014
2	Congenital Pain Insensitivity 03/2016 - 11/2014
2	Bipolar Disorder (Manic Depressive Psychosis) 01/2015 - 10/2013
2	Sleep Wake Disorders 11/2014 - 07/2011
2	Hereditary Sensory and Autonomic Neuropathies (HSAN) 01/2013 - 08/2011
1	Cognitive Dysfunction 11/2022
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2022
1	Moyamoya Disease (Moya-Moya Disease) 01/2022
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 10/2019
1	Specific Language Disorder 01/2017
1	Intellectual Disability (Idiocy) 01/2017
1	Multiple System Atrophy 01/2017
1	Synucleinopathies 01/2017
1	Seizures (Absence Seizure) 11/2016
1	Glut1 Deficiency Syndrome 11/2016
1	Autosomal Recessive Primary Microcephaly 04/2016
1	Pain (Aches) 03/2016
1	Neuralgia (Stump Neuralgia) 03/2016
1	Hyperalgesia 03/2016
1	Mental Disorders (Mental Disorder) 01/2016
1	Distal Myopathies (Distal Muscular Dystrophy) 01/2016
1	Lethal Arthrogryposis With Anterior Horn Cell Disease 03/2015
1	Lethal congenital contracture syndrome 1 03/2015
1	Motor Neuron Disease (Primary Lateral Sclerosis) 03/2015
1	Anosmia 11/2014
1	Late Onset Disorders 10/2014
1	Tremor (Tremors) 08/2014
1	Idiopathic Generalized Epilepsy 07/2014
1	Amyotrophic Lateral Sclerosis 8 06/2013
1	Parkinsonian Disorders (Parkinsonism) 02/2013
1	Agenesis of Corpus Callosum 01/2013
1	Neoplasms (Cancer) 01/2013
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 11/2012
1	Paraplegia (Spastic Paraplegia) 09/2012
1	Ataxia (Dyssynergia) 09/2012
1	Spastic Ataxia 09/2012

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2010
5	K Cl- CotransportersIBA 10/2017 - 01/2013
4	Potassium Chloride FDA LinkGeneric 10/2017 - 08/2011
3	Biological ProductsIBA 01/2022 - 08/2011
3	Nonsense Codon (Nonsense Mutation)IBA 01/2015 - 08/2012
2	Pharmaceutical PreparationsIBA 11/2022 - 08/2014
2	RNA (Ribonucleic Acid)IBA 04/2019 - 01/2016
2	polyalanineIBA 04/2019 - 06/2007
2	SynucleinsIBA 01/2019 - 11/2014
2	Glucosylceramidase (Glucocerebrosidase)IBA 10/2016 - 09/2011
2	DNA (Deoxyribonucleic Acid)IBA 01/2016 - 10/2014
2	LithiumIBA 01/2015 - 10/2013
2	Protein Isoforms (Isoforms)IBA 01/2013 - 09/2012
1	Polytetrafluoroethylene (Teflon)FDA Link 11/2022
1	N-Methylaspartate (NMDA)IBA 11/2022
1	Glutamic Acid (Glutamate)FDA Link 11/2022
1	Prednisolone (Predate)FDA LinkGeneric 10/2021
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 10/2019
1	Poly(A)-Binding Protein IIIBA 04/2019
1	MineralsIBA 01/2019
1	AcidsIBA 01/2019
1	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2019
1	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 01/2017
1	Apolipoproteins E (ApoE)IBA 01/2017
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 12/2016
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 11/2016
1	EnzymesIBA 10/2016
1	Phosphotransferases (Kinase)IBA 03/2016
1	gamma-Aminobutyric Acid (GABA)IBA 03/2016
1	Aminobutyrates (Aminobutyric Acid)IBA 03/2016
1	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2016
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2016
1	Protein Disulfide-IsomerasesIBA 07/2015
1	Genetic Markers (Genetic Marker)IBA 06/2015
1	Messenger RNA (mRNA)IBA 03/2015
1	Voltage-Gated Sodium ChannelsIBA 11/2014
1	Biomarkers (Surrogate Marker)IBA 08/2014
1	Immunoglobulin E (IgE)IBA 07/2014
1	R-SNARE Proteins (Vesicle-Associated Membrane Protein)IBA 06/2013
1	IgA receptor (protein B)IBA 06/2013
1	Profilins (Profilin)IBA 04/2013
1	Microfilament Proteins (Actin Binding Proteins)IBA 04/2013
1	Levodopa (L Dopa)FDA LinkGeneric 02/2013
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 01/2013
1	Arginine (L-Arginine)FDA Link 11/2012
1	Vesicle-Associated Membrane Protein 1IBA 09/2012
1	UbiquitinsIBA 09/2012
1	ProgranulinsIBA 08/2012
1	SymportersIBA 08/2011
1	Mutant Proteins (Protein, Mutant)IBA 08/2011
1	IronIBA 07/2011

Therapy/Procedure

2	Therapeutics 12/2021 - 04/2019